Interstitial lung disease (ILD) is one of the most common causes of death in connective tissue disease (CTD) and vasculitis. The physiological mechanism is not yet fully understood but it is characterized by a tight and complex interaction between environmental exposure, genetic and epigenetic predisposition, activation of the immune system, and cellular trans-differentiation. A proportion of patients affected by single conditions will develop progression of the disease. The most common and studied conditions associated with autoimmune ILD are scleroderma spectrum disorders and rheumatoid arthritis. In this chapter, we focused on the diagnosis, risk factors, pathophysiology, and treatment of these conditions.
Autoimmunity in interstitial lung disease
Sambataro G.
;
2022-01-01
Abstract
Interstitial lung disease (ILD) is one of the most common causes of death in connective tissue disease (CTD) and vasculitis. The physiological mechanism is not yet fully understood but it is characterized by a tight and complex interaction between environmental exposure, genetic and epigenetic predisposition, activation of the immune system, and cellular trans-differentiation. A proportion of patients affected by single conditions will develop progression of the disease. The most common and studied conditions associated with autoimmune ILD are scleroderma spectrum disorders and rheumatoid arthritis. In this chapter, we focused on the diagnosis, risk factors, pathophysiology, and treatment of these conditions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
