The World Health Organization has reported that cardiovascular diseases (CVDs) are the primary cause of mortality worldwide. Although current treatments reduce hypertension, palpitation, cholesterol and vessel narrowing, they can cause several side effects such fatigue and shortness of breath. In recent years, many researchers have paid special attention to the natural polyphenols that exert vasodilator effect and are able to manage lipid profiles in the human system. Among these flavonoids, baicalein has been shown to have a strong vasorelaxing effect and powerful antioxidant proprieties, probably due to presence of a di-ortho-hydroxyl functional group on ring-A. Baicalein is one of the flavonoids isolated from the dried root of Scutellaria baicalensis and it is metabolized in the intestine and liver in conjugated forms, responsible for its in vivo effects. Baicalein exhibits multiple biological effects to ameliorate some human diseases including cancers, autoimmune disorders, neurological disorders and inflammatory diseases. In this chapter, we discuss cardioprotective features of baicalein in CVDs, focusing on myocardial ischemia/reperfusion injury.
Baicalein Extract from Chinese Herbal Medicine to Use in Cardiovascular Diseases
D'Amico, Ramona;
2023-01-01
Abstract
The World Health Organization has reported that cardiovascular diseases (CVDs) are the primary cause of mortality worldwide. Although current treatments reduce hypertension, palpitation, cholesterol and vessel narrowing, they can cause several side effects such fatigue and shortness of breath. In recent years, many researchers have paid special attention to the natural polyphenols that exert vasodilator effect and are able to manage lipid profiles in the human system. Among these flavonoids, baicalein has been shown to have a strong vasorelaxing effect and powerful antioxidant proprieties, probably due to presence of a di-ortho-hydroxyl functional group on ring-A. Baicalein is one of the flavonoids isolated from the dried root of Scutellaria baicalensis and it is metabolized in the intestine and liver in conjugated forms, responsible for its in vivo effects. Baicalein exhibits multiple biological effects to ameliorate some human diseases including cancers, autoimmune disorders, neurological disorders and inflammatory diseases. In this chapter, we discuss cardioprotective features of baicalein in CVDs, focusing on myocardial ischemia/reperfusion injury.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
