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A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, asso...

The role of affective temperaments on depressive rumination in individuals with bruxism

Bruxism, defined as the grinding or clenching of teeth, is a multifactorial condition whose etiology involves both psychological and psychopathological aspects. In particular, it has been associated with variables such as anxiety, depression, and ruminative thinking. The aim of the present study is to examine the psychological characteristics associated with bruxism, with a particular focus on affective temperaments and depressive rumination. The subjects recruited from the general population...

Clinical Safety and Healing Outcomes of an Essential-Oil Gel Versus Hyaluronic Acid: A Randomized Controlled Trial After Tooth Extraction

Introduction: – Interest in natural therapeutic approaches in dentistry has grown, particularly for postoperative management following tooth extraction. If the clinical efficacy and tolerability of essential oils and hyaluronic acid are comparable, then they might be a safe alternative. The purpose of this study was to compare the efficacy and safety of essential-oil-based GelCide (essential-oil-based gel) and hyaluronic-acid-based Gengigel (hyaluronic-acid-based gel) for alveolar wound heali...

Electrically Charged Lipid Nanoparticles as Intracanal Antimicrobial Delivery Systems: A Narrative Review of Preclinical Evidence for Biofilm Control

Background: Persistent endodontic infections remain a significant challenge in root canal therapy, primarily due to the complexity of root canal anatomy and the formation of resistant microbial biofilms. Conventional irrigants, including sodium hypochlorite and chlorhexidine, show limited penetration into dentinal tubules and reduced efficacy against mature biofilms, contributing to treatment failure. Electrically charged lipid nanoparticles (ECLNs), such as cationic solid lipid nanoparticles...

Comparative analysis of large language models as decision support tools in oral pathology

This study evaluated the performance of four large language model based chatbots (LLMs) (ChatGPT-4.0, ChatGPT o1-preview, Gemini, and Meta AI) as decision-support systems for interpreting histopathologic descriptions of oral lesions, assessing agreement between their s generated a suggested primary interpretation and three differential diagnoses. Outputs were categorized as Different, Similar, or Correct compared to the consensus reference diagnosis established by two board-certified patholog...

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