Spondylodiscitis, an infection involving the verte‑brae and interposed discs, can arise from hematogenous spreador from direct virulent inoculation during spinal surgery.Symptoms are non‑specific, with a subacute clinical course.Currently, the severe acute respiratory syndrome‑coronavirus2 (SARS‑CoV‑2) pandemic has led to a further delay in diag‑nosis, with devastating consequences and complications. Thepresent study presents a case series with the aim of describingthe etiology, clinical characteristics and complications ofthe cases of spondylodiscitis observed. The present study isa single‑center retrospective case series of cases observedduring the period from January 1 to June 30, 2022. Datawere collected anonymously in an electronic spreadsheet. Allpatients signed a general informed consent to allow the anony‑mous use of their data upon admission. A total of 6 patientswere admitted to hospital during the period of interest;5 cases were primary cases (83.3%). During the same periodin 2019, before the SARS‑CoV‑2 pandemics, only 2 cases ofspondylodiscitis were diagnosed and treated, both primaryinfections. In 3 cases (50.0%) the infection only involved thelumbar vertebrae, in 2 cases (33.3%) it involved the dorsaland lumbar vertebrae, in 1 case it involved the localizationwas in the dorsal vertebrae (16.7%) and in another case, onlythe cervical vertebrae were involved (16.7%). Etiology wasidentified in a Gram‑positive germ [Staphylococcus sciuri,St reptococcus agalactiae, E nterococcus faecalis;methicillin‑resistant Staphylococcus aureus (MRSA)] in4 cases (66.6%), and in both a Gram‑positive (MRSA) anda Gram‑negative germ (Pseudomonas aeruginosa) in 1 case(16.6%). Of note, 1 case remained undetermined (16.6%). In2 cases, an endocarditis secondary to primary spondylodiscitiswas also found. On the whole, spondylodiscitis is a rare infec‑tious disease with a subacute course, the origin of which oftenremains unrecognized. During the SARS‑CoV‑2 pandemic,the diagnostic delay led to an increase of >300% in the diag‑noses at the authors' center and a worsening of the prognosis. (PDF) High prevalence of pyogenic spondylodiscitis cases in a third level university infectious diseases center: A case series and literature review.
High prevalence of pyogenic spondylodiscitis cases in a third level university infectious diseases center: A case series and literature review
Ceccarelli, Manuela;
2023-01-01
Abstract
Spondylodiscitis, an infection involving the verte‑brae and interposed discs, can arise from hematogenous spreador from direct virulent inoculation during spinal surgery.Symptoms are non‑specific, with a subacute clinical course.Currently, the severe acute respiratory syndrome‑coronavirus2 (SARS‑CoV‑2) pandemic has led to a further delay in diag‑nosis, with devastating consequences and complications. Thepresent study presents a case series with the aim of describingthe etiology, clinical characteristics and complications ofthe cases of spondylodiscitis observed. The present study isa single‑center retrospective case series of cases observedduring the period from January 1 to June 30, 2022. Datawere collected anonymously in an electronic spreadsheet. Allpatients signed a general informed consent to allow the anony‑mous use of their data upon admission. A total of 6 patientswere admitted to hospital during the period of interest;5 cases were primary cases (83.3%). During the same periodin 2019, before the SARS‑CoV‑2 pandemics, only 2 cases ofspondylodiscitis were diagnosed and treated, both primaryinfections. In 3 cases (50.0%) the infection only involved thelumbar vertebrae, in 2 cases (33.3%) it involved the dorsaland lumbar vertebrae, in 1 case it involved the localizationwas in the dorsal vertebrae (16.7%) and in another case, onlythe cervical vertebrae were involved (16.7%). Etiology wasidentified in a Gram‑positive germ [Staphylococcus sciuri,St reptococcus agalactiae, E nterococcus faecalis;methicillin‑resistant Staphylococcus aureus (MRSA)] in4 cases (66.6%), and in both a Gram‑positive (MRSA) anda Gram‑negative germ (Pseudomonas aeruginosa) in 1 case(16.6%). Of note, 1 case remained undetermined (16.6%). In2 cases, an endocarditis secondary to primary spondylodiscitiswas also found. On the whole, spondylodiscitis is a rare infec‑tious disease with a subacute course, the origin of which oftenremains unrecognized. During the SARS‑CoV‑2 pandemic,the diagnostic delay led to an increase of >300% in the diag‑noses at the authors' center and a worsening of the prognosis. (PDF) High prevalence of pyogenic spondylodiscitis cases in a third level university infectious diseases center: A case series and literature review.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
