B cell receptor (BCR) critically contributes to the growth of multiple types of mature B cell neoplasms, representing a preferred target of therapy. Strikingly, whereas IgH SP sp DHL/THL GCB lymphomas retained IgM expression, IgH SP UND sp lymphomas systematically completed IgH class-switching, yet failed to assemble signaling-competent Ig/CD79B/A BCR complexes.
IMMUNOGLOBULIN CLASS DICTATES TRANSFORMATION TRAJECTORY AND BCR STATUS OF MYC/BCL2 DOUBLE‐HIT LYMPHOMA: BIOLOGY AND CLINICAL IMPLICATIONS
Bertolazzi, G.;Di Napoli, A.;
2023-01-01
Abstract
B cell receptor (BCR) critically contributes to the growth of multiple types of mature B cell neoplasms, representing a preferred target of therapy. Strikingly, whereas IgH SP sp DHL/THL GCB lymphomas retained IgM expression, IgH SP UND sp lymphomas systematically completed IgH class-switching, yet failed to assemble signaling-competent Ig/CD79B/A BCR complexes.File in questo prodotto:
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