Purpose: : To evaluate the morphology of photoreceptor layer (by spectral-domain optical coherence tomography, SD-OCT) and the functional parameters in patients with lamellar macular hole (LMH). Methods: : Fifty-four patients with LMH were enrolled in the study. All patients underwent a complete ophthalmological examination including best correct visual acuity (BCVA) testing (LogMar), MP1 microperimetry and SD-OCT. For each patient, 2 experienced masked observers evaluated the integrity of photoreceptors inner segment/outer segment junction (IS/OS line) and external limiting membrane (ELM line). The reliability of IS/OS line and ELM line grading was determined with weighted k statistics and intraclass correlation coefficients (ICC). Results: : SD-OCT analysis showed in 40 eyes a complete integrity of IS/OS and ELM lines (group A), in 8 eyes a partial or complete disruption of IS/OS line with an intact ELM line (group B), and in 6 eyes an alteration of both IS/OS and ELM lines (group C). The ICC between observers for the grading of the IS/OS line was 0.955 and for the the ELM line was 0.815. The K coefficient for the status of the IS/OS line was 0.906 and for the status of the ELM line was 0.813. Mean BCVA, total retinal sensitivity, percentage of fixation points within 2 and 4 degree were significantly better in groups A and B than in group C (P < .01, Tukey-Kramer test), while there was no significant difference between group A and B (P = not significant). Mean central retinal sensitivity of Group A and B was significantly higher than Group C (P < .01, Tukey-Kramer test), and that of Group A was significantly higher than Group B (P < .05, Tukey-Kramer test). The degree of integrity of foveal photoreceptor layer was significantly correlated with mean BCVA (r = - 0.568; P < 0.000), mean central retinal sensitivity (r = 0.519; P < 0.000), total retinal sensitivity (r = 0.444; P = 0.001), but not with fixation stability inside the 2 and 4 degrees. Conclusions: : In eyes with LMH, morphology of foveal photoreceptor layer is consistently correlated with BCVA and central retinal sensitivity. Preservation of the ELM is related to the maintenance of visual functions.
Foveal Microstructure And Functional Parameters In Eyes With Lamellar Macular Hole
Gagliano C;
2012-01-01
Abstract
Purpose: : To evaluate the morphology of photoreceptor layer (by spectral-domain optical coherence tomography, SD-OCT) and the functional parameters in patients with lamellar macular hole (LMH). Methods: : Fifty-four patients with LMH were enrolled in the study. All patients underwent a complete ophthalmological examination including best correct visual acuity (BCVA) testing (LogMar), MP1 microperimetry and SD-OCT. For each patient, 2 experienced masked observers evaluated the integrity of photoreceptors inner segment/outer segment junction (IS/OS line) and external limiting membrane (ELM line). The reliability of IS/OS line and ELM line grading was determined with weighted k statistics and intraclass correlation coefficients (ICC). Results: : SD-OCT analysis showed in 40 eyes a complete integrity of IS/OS and ELM lines (group A), in 8 eyes a partial or complete disruption of IS/OS line with an intact ELM line (group B), and in 6 eyes an alteration of both IS/OS and ELM lines (group C). The ICC between observers for the grading of the IS/OS line was 0.955 and for the the ELM line was 0.815. The K coefficient for the status of the IS/OS line was 0.906 and for the status of the ELM line was 0.813. Mean BCVA, total retinal sensitivity, percentage of fixation points within 2 and 4 degree were significantly better in groups A and B than in group C (P < .01, Tukey-Kramer test), while there was no significant difference between group A and B (P = not significant). Mean central retinal sensitivity of Group A and B was significantly higher than Group C (P < .01, Tukey-Kramer test), and that of Group A was significantly higher than Group B (P < .05, Tukey-Kramer test). The degree of integrity of foveal photoreceptor layer was significantly correlated with mean BCVA (r = - 0.568; P < 0.000), mean central retinal sensitivity (r = 0.519; P < 0.000), total retinal sensitivity (r = 0.444; P = 0.001), but not with fixation stability inside the 2 and 4 degrees. Conclusions: : In eyes with LMH, morphology of foveal photoreceptor layer is consistently correlated with BCVA and central retinal sensitivity. Preservation of the ELM is related to the maintenance of visual functions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
