We retrospectively examined brain MRI, clinical and EEC data of 266 patients with mental retardation to evaluate the prevalence of neuronal migration disorders and cortical organization and to analyze the possible relations between anatomic anomalies and clinical and EEG findings. Twenty-two patients had brain malformations (8.3%). Seventeen patients (77.3%) belonged to the group with mental retardation and epilepsy, the other five presented only mental retardation without seizures or EEG abnormalities. A spatial correlation between EEG and MRI anomalies was demonstrated in 7/17 patients (41.2%). We discuss the importance of a correct MRI-EEG correlation in subjects with neuronal migration disorders and drug-resistant epilepsy, also in view of possible surgery.
Neuronal migration disorders and cortical anomalies in epilepsy - Electroclinical and magnetic resonance correlations
Elia M;
1998-01-01
Abstract
We retrospectively examined brain MRI, clinical and EEC data of 266 patients with mental retardation to evaluate the prevalence of neuronal migration disorders and cortical organization and to analyze the possible relations between anatomic anomalies and clinical and EEG findings. Twenty-two patients had brain malformations (8.3%). Seventeen patients (77.3%) belonged to the group with mental retardation and epilepsy, the other five presented only mental retardation without seizures or EEG abnormalities. A spatial correlation between EEG and MRI anomalies was demonstrated in 7/17 patients (41.2%). We discuss the importance of a correct MRI-EEG correlation in subjects with neuronal migration disorders and drug-resistant epilepsy, also in view of possible surgery.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
