REdo transcatheter aortic VALVE implantation for the management of transcatheter aortic valve failure: Design and rationale of the REVALVE study

Background: The expansion of transcatheter aortic valve implantation (TAVI) into younger and lower risk patients increases the likelihood of future reintervention on the valve due to bioprosthetic valve failure (BVF). However, little is known about the feasibility and outcomes of redo TAVI for BVF. Methods: REVALVE is an investigator-initiated, open-label, prospective registry, enrolling 300 patients undergoing redo TAVI in approximately 75 centres in 11 countries in Europe and the Middle East. The primary endpoint is REVALVE success at 30-days, adapted from the Valve Academic Research Consortium-3 (VARC-3) criteria and defined as the correct positioning of a single prosthetic heart valve into the proper anatomic location, intended performance of the valve (mean gradient <20 mmHg, peak velocity < 3.0 m/s, doppler velocity index ≥0.25,