This study evaluates the role of amplitude-integrated electroencephalogram (aEEG) in monitoring encephalopathy during metabolic crises in neonate with inborn errors of metabolism (IEM). In a case of isovaleric acidaemia, an inverse correlation is observed between ammonia levels and aEEG patterns. Elevated ammonia was linked to abnormal aEEG findings, while treatment of hyperammonaemia restored normal sleep–wake cycle and background, indicating recovery While not diagnostic for specific IEMs, aEEG serves as a crucial tool for assessing brain function and treatment efficacy in neonatal metabolic disorders.
Amplitude-integrated Electroencephalography in a Neonate with Isovaleric Acidaemia: A Case Report
Sortino, Vincenzo
2025-01-01
Abstract
This study evaluates the role of amplitude-integrated electroencephalogram (aEEG) in monitoring encephalopathy during metabolic crises in neonate with inborn errors of metabolism (IEM). In a case of isovaleric acidaemia, an inverse correlation is observed between ammonia levels and aEEG patterns. Elevated ammonia was linked to abnormal aEEG findings, while treatment of hyperammonaemia restored normal sleep–wake cycle and background, indicating recovery While not diagnostic for specific IEMs, aEEG serves as a crucial tool for assessing brain function and treatment efficacy in neonatal metabolic disorders.File in questo prodotto:
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