Effectiveness of an Active Offer of Influenza Vaccination to Hospitalized Frail Patients

settingsOrder Article Reprints Open AccessArticle Effectiveness of an Active Offer of Influenza Vaccination to Hospitalized Frail Patients by Alessandra Fallucca 1ORCID,Davide Anzà 2ORCID,Claudio Costantino 1ORCID,Cristina Genovese 3ORCID,Giovanni Genovese 3ORCID,Caterina Elisabetta Rizzo 3,Tania Vitello 1,Luigi Zagra 1 andVincenzo Restivo 2,*ORCID 1 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Excellence Specialties “G. D’Alessandro”, University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy 2 School of Medicine, University Kore of Enna, Via delle Olimpiadi 4, 94100 Enna, Italy 3 Department of Biomedical Sciences and Morphological and Functional Images (BIOMORF), University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy * Author to whom correspondence should be addressed. Vaccines 2025, 13(11), 1165; https://doi.org/10.3390/vaccines13111165 Submission received: 5 October 2025 / Revised: 11 November 2025 / Accepted: 13 November 2025 / Published: 15 November 2025 (This article belongs to the Special Issue Factors Affecting and Strategies Enhancing the Willingness to Receive and Uptake of Seasonal Influenza Vaccination) Downloadkeyboard_arrow_down Review Reports Versions Notes Abstract Background/Objectives: Following the COVID-19 pandemic, the influenza season returned to its typical pre-pandemic circulation patterns. The category of people most vulnerable to severe influenza was older adults, and frail individuals, confirming their central role as a priority group for vaccination. The objective of this study was to evaluate the impact of an active influenza vaccination program in an area with low influenza vaccination rates and propensity to vaccine co-administration. Methods: People recruited were hospitalized frail individuals, patients over the age of 60, and those with chronic illnesses or comorbidities. It was administered a questionnaire to investigate adherence to influenza vaccination and the Health Action Process Approach was used to evaluate the propensity to co-administration. Results: A total of 418 hospitalized patients were enrolled in the study, of whom 58.4% (n = 244) received the influenza vaccine and 17.9% (n = 75) had a higher propensity to have co-administration of influenza and other recommended vaccines. The factors associated with influenza vaccination acceptance were received advice from hospital healthcare workers (aOR = 10.6 p < 0.001) and previous influenza vaccination (aOR = 18.1; p < 0.001). Propensity to vaccine co-administration was associated with a higher educational level (aOR = 4.21; p = 0.002), receiving vaccination advice from hospital healthcare workers (aOR = 2.80; p = 0.03), perceived positive outcome (aOR = 1.29; p = 0.02) and perceived self-efficacy (aOR = 1.48; p < 0.001). Conslusions: This study explored the impact on influenza vaccination coverage in implementing in hospital vaccination offer. The reliability of this strategy, together with the standard vaccination offer, could allow reaching the recommended vaccination coverage, particularly among at-risk people.