Clinical and molecular heterogeneity in advanced-stage POLE-mutated endometrial carcinoma: a focus on aggressive subsets and co-mutations

Navigating the diagnostic maze of renal tuberculosis in advanced chronic kidney disease: A case report

Renal tuberculosis (TB) is a rare extrapulmonary manifestation of Mycobacterium tuberculosis, often leading to irreversible renal damage due to delays in diagnosis. The present study reports the case of a 72-year-old male patient with pre-existing type II diabetes mellitus, hypertension, and stage G3bA0 chronic kidney disease (CKD), who manifested with a sub-acute deterioration of renal function necessitating renal replacement therapy. The initial workup for uropathies, including repeated uri...

Efficacy of Automatic Dynamic Ultrafiltration Compared to Constant Ultrafiltration Methods on Hypovolemic Intradialytic Symptoms: A Single-center Experience

Background. Hypovolemic intradialytic complications, including cramps, fatigue, and hypotension, are common in hemodialysis patients. Bioimpedance spectroscopy is the gold standard for fluid assessment, but it is not available in all dialysis centers. Ultrasound techniques can help clinicians, but they are operator-dependent and time-consuming. Ultrafiltration control (UF-control), a newer technology, allows for continuous monitoring of real-time blood volume changes (RBV%) and it adjusts ult...

Impact of RAAS blockers on serum potassium and mortality in a large dialysis cohort: a longitudinal analysis

Abstract Background Renin–angiotensin–aldosterone system inhibitors (RAASIs) are widely used antihypertensive drugs. Due to the hyperkalaemic effect, previous 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines discouraged RAASI use in patients with severe chronic kidney disease (CKD). However, due to the recently discovered cardioprotective and nephroprotective effects, the 2022 KDIGO guidelines suggest their use in CKD stage 4–5. To our knowledge, few studies have explored the...